Publications 2018-07-13T00:56:09+00:00
  • Li F, Zhang N, Gorantla S, Gilbertson SR, Pati D. The Metabolism of Separase Inhibitor Sepin-1 in Human, Mouse, and Rat Liver Microsomes. Front Pharmacol. 2018; 9:313. PMID: 29867452.
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  • Zhang N, Pati D. Separase Inhibitor Sepin-1 Inhibits Foxm1 Expression and Breast Cancer Cell Growth. J Cancer Sci Ther. 2018; 10(3). PMID: 29780443.
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  • Yen F-Y, Pati D, Merchant F. Proceeding of SPIE. 3D Modelling of chromosomes territories in normal and aneuploid nuclei. 2018; 10578(105782K-1):1-10.
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  • Zhang N, Pati D. Biology and insights into the role of cohesin protease separase in human malignancies. Biol Rev Camb Philos Soc. 2017 Feb 08. PMID: 28177203.
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  • Do HT, Zhang N, Pati D, Gilbertson SR. Synthesis and activity of benzimidazole-1,3-dioxide inhibitors of separase. Bioorg Med Chem Lett. 2016 Sep 15; 26(18):4446-50. PMID: 27530289.
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  • Chen Y, Terajima M, Yang Y, Sun L, Ahn YH, Pankova D, Puperi DS, Watanabe T, Kim MP, Blackmon SH, Rodriguez J, Liu H, Behrens C, Wistuba II, Minelli R, Scott KL, Sanchez-Adams J, Guilak F, Pati D, Thilaganathan N, Burns AR, Creighton CJ, Martinez ED, Zal T, Grande-Allen KJ, Yamauchi M, Kurie JM. Lysyl hydroxylase 2 induces a collagen cross-link switch in tumor stroma. J Clin Invest. 2015 Mar 2; 125(3):1147-62. PMID: 25664850; PMCID: PMC4362236.
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  • Zhang N, Pati D. C-terminus of Sororin interacts with SA2 and regulates sister chromatid cohesion. Cell Cycle. 2015; 14(6):820-6. PMID: 25608232; PMCID: PMC4614265.
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  • Mukherjee M, Byrd T, Brawley VS, Bielamowicz K, Li XN, Merchant F, Maitra S, Sumazin P, Fuller G, Kew Y, Sun D, Powell SZ, Ahmed N, Zhang N, Pati D. Erratum to: Overexpression and constitutive nuclear localization of cohesin protease Separase protein correlates with high incidence of relapse and reduced overall survival in glioblastoma multiforme. J Neurooncol. 2014 Aug; 119(1):37. PMID: 24902668.
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  • Zhang N, Scorsone K, Ge G, Kaffes CC, Dobrolecki LE, Mukherjee M, Lewis MT, Berg S, Stephan CC, Pati D. Identification and Characterization of Separase Inhibitors (Sepins) for Cancer Therapy. J Biomol Screen. 2014 Jul; 19(6):878-89. PMID: 24525869.
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  • Shete A, Rao P, Pati D, Merchant F. Spatial quantitation of FISH signals in diploid versus aneuploid nuclei. Cytometry A. 2014 Apr; 85(4):339-52. PMID: 24347051; PMCID: PMC3972278.
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  • Mukherjee M, Ge G, Zhang N, Edwards DG, Sumazin P, Sharan SK, Rao PH, Medina D, Pati D. MMTV-Espl1 transgenic mice develop aneuploid, estrogen receptor alpha (ER?)-positive mammary adenocarcinomas. Oncogene. 2014 Nov 27; 33(48):5511-22. PMID: 24276237; PMCID: PMC4032816.
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  • Zhang N, Jiang Y, Mao Q, Demeler B, Tao YJ, Pati D. Characterization of the interaction between the cohesin subunits Rad21 and SA1/2. PLoS One. 2013; 8(7):e69458. PMID: 23874961; PMCID: PMC3709894.
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  • Pati D and Zhang N. SEPARASE INHIBITORS AND USES THEREOF . 2013.
  • Zhang, N. and Pati, D. . Oncology. Path to cancer via Cohesin. 2013.
  • Panigrahi AK, Pati D. Higher-order orchestration of hematopoiesis: is cohesin a new player? Exp Hematol. 2012 Dec; 40(12):967-73. PMID: 23022223; PMCID: PMC3595174.
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  • Zhang N, Pati D. Sororin is a master regulator of sister chromatid cohesion and separation. Cell Cycle. 2012 Jun 1; 11(11):2073-83. PMID: 22580470; PMCID: PMC3368859.
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  • Panigrahi AK, Zhang N, Otta SK, Pati D. A cohesin-RAD21 interactome. Biochem J. 2012 Mar 15; 442(3):661-70. PMID: 22145905.
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  • Zhang N, Panigrahi AK, Mao Q, Pati D. Interaction of Sororin protein with polo-like kinase 1 mediates resolution of chromosomal arm cohesion. J Biol Chem. 2011 Dec 2; 286(48):41826-37. PMID: 21987589; PMCID: PMC3310079.
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  • Panigrahi AK, Zhang N, Mao Q, Pati D. Calpain-1 cleaves Rad21 to promote sister chromatid separation. Mol Cell Biol. 2011 Nov; 31(21):4335-47. PMID: 21876002; PMCID: PMC3209327.
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  • Mukherjee M, Ge G, Zhang N, Huang E, Nakamura LV, Minor M, Fofanov V, Rao PH, Herron A, Pati D. Separase loss of function cooperates with the loss of p53 in the initiation and progression of T- and B-cell lymphoma, leukemia and aneuploidy in mice. PLoS One. 2011; 6(7):e22167. PMID: 21799785; PMCID: PMC3143119.
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  • Horton TM, Jenkins G, Pati D, Zhang L, Dolan ME, Ribes-Zamora A, Bertuch AA, Blaney SM, Delaney SL, Hegde M, Berg SL. Poly(ADP-ribose) polymerase inhibitor ABT-888 potentiates the cytotoxic activity of temozolomide in leukemia cells: influence of mismatch repair status and O6-methylguanine-DNA methyltransferase activity. Mol Cancer Ther. 2009 Aug; 8(8):2232-42. PMID: 19671751; PMCID: PMC3741063.
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  • Basu D, Zhang N, Panigrahi AK, Horton TM, Pati D. Development and validation of a fluorogenic assay to measure separase enzyme activity. Anal Biochem. 2009 Sep 15; 392(2):133-8. PMID: 19497291; PMCID: PMC2713383.
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  • Meyer R, Fofanov V, Panigrahi A, Merchant F, Zhang N, Pati D. Overexpression and mislocalization of the chromosomal segregation protein separase in multiple human cancers. Clin Cancer Res. 2009 Apr 15; 15(8):2703-10. PMID: 19351757; PMCID: PMC2718850.
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  • Zhang N, Pati D. Handcuff for sisters: a new model for sister chromatid cohesion. Cell Cycle. 2009 Feb 1; 8(3):399-402. PMID: 19177018; PMCID: PMC2689371.
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  • Panigrahi AK, Pati D. Road to the crossroads of life and death: linking sister chromatid cohesion and separation to aneuploidy, apoptosis and cancer. Crit Rev Oncol Hematol. 2009 Dec; 72(3):181-93. PMID: 19162508; PMCID: PMC2783576.
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  • Zhang N, Kuznetsov SG, Sharan SK, Li K, Rao PH, Pati D. A handcuff model for the cohesin complex. J Cell Biol. 2008 Dec 15; 183(6):1019-31. PMID: 19075111; PMCID: PMC2600748.
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  • Pati D. Oncogenic activity of separase. Cell Cycle. 2008 Nov 15; 7(22):3481-2. PMID: 19001849; PMCID: PMC2613011.
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  • Zhang N, Ge G, Meyer R, Sethi S, Basu D, Pradhan S, Zhao YJ, Li XN, Cai WW, El-Naggar AK, Baladandayuthapani V, Kittrell FS, Rao PH, Medina D, Pati D. Overexpression of Separase induces aneuploidy and mammary tumorigenesis. Proc Natl Acad Sci U S A. 2008 Sep 2; 105(35):13033-8. PMID: 18728194; PMCID: PMC2529090.
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  • Lu XY, Lu Y, Zhao YJ, Jaeweon K, Kang J, Xiao-Nan L, Ge G, Meyer R, Perlaky L, Hicks J, Chintagumpala M, Cai WW, Ladanyi M, Gorlick R, Lau CC, Pati D, Sheldon M, Rao PH. Cell cycle regulator gene CDC5L, a potential target for 6p12-p21 amplicon in osteosarcoma. Mol Cancer Res. 2008 Jun; 6(6):937-46. PMID: 18567798; PMCID: PMC2693718.
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  • Horton TM, Pati D, Plon SE, Thompson PA, Bomgaars LR, Adamson PC, Ingle AM, Wright J, Brockman AH, Paton M, Blaney SM. A phase 1 study of the proteasome inhibitor bortezomib in pediatric patients with refractory leukemia: a Children’s Oncology Group study. Clin Cancer Res. 2007 Mar 1; 13(5):1516-22. PMID: 17332297.
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  • Kuznetsov S, Pellegrini M, Shuda K, Fernandez-Capetillo O, Liu Y, Martin BK, Burkett S, Southon E, Pati D, Tessarollo L, West SC, Donovan PJ, Nussenzweig A, Sharan SK. RAD51C deficiency in mice results in early prophase I arrest in males and sister chromatid separation at metaphase II in females. J Cell Biol. 2007 Feb 26; 176(5):581-92. PMID: 17312021; PMCID: PMC2064017.
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  • Zhang, N., Pradhan, S, Jena, B., Rao, P, Pati D. . Role of a Novel Separase Interacting Protein Insep5/Sororin in Sister Chromatid Cohesion and Separation. FASEB Journal. 2007; (21):813-814.
  • Pati D, Haddad BR, Haegele A, Thompson H, Kittrell FS, Shepard A, Montagna C, Zhang N, Ge G, Otta SK, McCarthy M, Ullrich RL, Medina D. Hormone-induced chromosomal instability in p53-null mammary epithelium. Cancer Res. 2004 Aug 15; 64(16):5608-16. PMID: 15313898.
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  • Pati D, Zhang N, Plon SE. Linking sister chromatid cohesion and apoptosis: role of Rad21. Mol Cell Biol. 2002 Dec; 22(23):8267-77. PMID: 12417729; PMCID: PMC134054.
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